The Twist: Jobu Tupaki is not trying to kill Evelyn; she is trying to find an Evelyn who can understand her so they can enter the 'Everything Bagel' (void/suicide) together. Jobu is essentially a depressed daughter reaching out.
The Resolution: Evelyn confronts Gong Gong, telling him that Joy is gay and that it's okay. She then fights her way to Joy not with punches, but by giving the attacking minions what they truly need (happiness, relief from pain). Evelyn pulls Joy back from the Bagel, not by fixing everything, but by promising that no matter what other universes exist, she chooses to be here with Joy.
The Final Shot: The film ends back in the mundane tax office. Evelyn is momentarily distracted by the multiverse/noise but snaps back to focus on the tax auditor, symbolizing that she has integrated her awareness and chosen to be present in her current reality.