Me Against You: Mr. S's Vendetta - Ending Explained

In the film's climax, Luì and Sofì manage to escape the underground laboratory using their combined wits. They discover that Signor S's plan is to use the hypnotic slime, promoted by their clones, on all their fans gathered at a large event where the 'Like Award' is to be presented. The slime will make the children happy but also completely obedient to Signor S, allowing him to take over the world.

The duo rushes to the event and manages to get on stage, confronting their clones. They prove their identity to the audience through their genuine connection and inside jokes that the clones cannot replicate. Working together, they reverse the effects of the slime machine, freeing the children from its influence. Signor S's plan is foiled. In the ensuing chaos, the villain manages to escape in a spaceship, vowing to return and get his revenge. A significant plot point is that Signor S's true identity is not revealed in this film; he remains a mysterious figure in a mask, setting up the central conflict for the sequel, "Me contro Te - Il film: Il mistero della scuola incantata". His assistant, Professor Cattivius, is revealed to be a good person named Pongo who was being controlled by Signor S.