Common Side Effects
A psychedelic conspiracy thriller pulsating with dry humor and boiling rage. It is a neon-tinted fungal dream where clinical corporate sterility clashes with the untamed, healing warmth of the natural world.
Common Side Effects
Common Side Effects
02 February 2025 — 30 March 2025 United States of America 2 season 10 episode Returning Series ⭐ 8.4 (212)
Cast: Dave King, Emily Pendergast, Mike Judge, Martha Kelly, Joseph Lee Anderson
Drama Animation Sci-Fi & Fantasy Comedy
Corporate Greed and Devaluation of Life Human Incompetence vs. Malice The Trap of Systemic Debt Psychedelia and Spiritual Awakening

Common Side Effects - Characters & Cast

Character Analysis

Marshall Cuso

Dave King

Archetype: The Reluctant Prophet
Key Trait: Principled Idealism

Motivation

To democratize healthcare and ensure the Blue Angel mushroom is free for everyone, driven by a deep, non-violent love for humanity and nature.

Character Arc

Marshall begins as an awkward, socially isolated mycologist. Over two seasons, he evolves from a victim of the system into an international fugitive and spiritual leader, eventually accepting that the mushroom's distribution requires him to step into a position of dangerous influence.

Frances Applewhite

Emily Pendergast

Archetype: The Everywoman
Key Trait: Moral Ambivalence

Motivation

Finding a way to care for her dementia-afflicted mother while escaping the crushing weight of her financial obligations.

Character Arc

Initially a pragmatist trapped by debt and corporate loyalty, Frances undergoes a moral awakening. She eventually betrays her employers at Reutical, realizing that her survival is intrinsically linked to Marshall's mission.

Rick Kruger

Mike Judge

Archetype: The Bumbling Bureaucrat
Key Trait: Cheerful Incompetence

Motivation

Job security and maintaining his status quo, often more concerned with mundane office tasks than the global conspiracy he is leading.

Character Arc

The CEO of Reutical remains largely static—a satirical figure of corporate vapidity. However, his moments of accidental empathy and his obsession with farming simulators reveal a man completely detached from the consequences of his company's actions.

Jonas Backstein

Danny Huston

Archetype: The Shadow Antagonist
Key Trait: Calculating Ruthlessness

Motivation

Personal survival at any cost; he wants the mushroom to cure his own cancer while keeping it from the public to maintain market control.

Character Arc

A ruthless board member who starts as a cold corporate shark but reveals his vulnerability through terminal illness. His arc ends in a horrific purgatory of his own making when he tries to hoard the mushroom's power.

Agent Copano

Joseph Lee Anderson

Archetype: The Truth-Seeker
Key Trait: Inquisitive Skepticism

Motivation

The need to "connect the dots" and uncover the truth behind the government’s involvement in pharmaceutical suppression.

Character Arc

A DEA agent whose initial obsession with conspiracy theories turns out to be justified. He eventually defects from the government to assist Marshall, becoming a protector of the very "drug" he was sent to destroy.

Cast

Dave King as Marshall Cuso (voice)
Emily Pendergast as Frances Applewhite (voice)
Mike Judge as Rick Kruger (voice)
Martha Kelly as Agent Harrington (voice)
Joseph Lee Anderson as Agent Copano (voice)
Sue Rose as Hildy (voice)
Shannon Woodward as Amelia (voice)
Ben Feldman as Nick (voice)
Sydney Tamiia Poitier as Cecily (voice)
Shalita Grant as Kelly (voice)
Danny Huston as Jonas Backstein (voice)
Steve Hely as Rusty (voice)
Christine Ko as Kiki (voice)
Alan Resnick as Zane (voice)
Lin Shaye as Sonia (voice)