The entire narrative of "Cyberpunk: Edgerunners" is built on a foundation of tragic foreshadowing. The central twist is that David Martinez is not, in fact, special. His high tolerance for cyberware, which he and his crew believe makes him "built different," is simply a temporary trait that Arasaka's fixer, Faraday, intends to exploit. Faraday manipulates the crew, secretly intending to use David as the unwilling test pilot for the cyberskeleton, a piece of military tech so powerful it inevitably drives its user insane. Unbeknownst to David, Lucy discovers Arasaka's plan and spends the latter half of the series secretly hunting down and killing Arasaka agents to protect him, which explains her growing distance and secrecy.
The crew is dismantled by internal and external forces. Kiwi, the crew's netrunner, betrays them to Faraday for a chance at a better life, though she has a last-minute change of heart and helps David locate Faraday before she is killed. The climax sees David voluntarily don the cyberskeleton to save Lucy, whom Faraday has captured. This act fully pushes him into cyberpsychosis. Most of the remaining crew, including the fan-favorite Rebecca, are killed in the ensuing battle. David's final confrontation is with Adam Smasher, a legendary full-borg solo from Arasaka. The fight is brutally one-sided. Smasher, intrigued by David's resilience, offers to make him an Arasaka "construct," but David refuses and is unceremoniously executed. His sacrifice allows Falco, the crew's driver, to escape with Lucy. The series ends with Lucy finally making it to the moon, her dream fulfilled, but she is utterly alone, haunted by a vision of David, revealing the heartbreaking emptiness of her victory.