The central plot twist unfolds as Ma, realizing their captor Old Nick is financially unstable and growing more dangerous, concocts a desperate escape plan. She has Jack fake a severe illness, but Old Nick only promises to bring antibiotics. The revised plan involves Jack playing dead, being rolled into a rug, with Ma convincing Old Nick that he has died and needs to be buried somewhere far away. The plan works; Old Nick places the rug in his pickup truck. Overwhelmed by his first experience of the outside world, Jack manages to unroll himself and jump out of the moving truck, flagging down a passerby who calls the police.
Jack, though terrified, is able to lead the police back to Room, where they rescue Ma and arrest Old Nick. The second half of the film is a deep analysis of the aftermath. Joy (Ma) is reunited with her parents, who are now divorced. Her father cannot bring himself to look at or accept Jack, a product of rape, and leaves. Joy struggles immensely with her trauma and the pressure of a media interview, which leads her to attempt suicide. While she recovers in a hospital, Jack begins to slowly acclimate to the world, bonding with his grandmother (Joan Allen). In a pivotal moment, Jack cuts his long hair—his symbol of strength—and sends it to his mother to help her heal. After her recovery, they find a new normal. At Jack's request, they visit Room one last time. He finds the space shockingly small and says, "It can't really be Room if the door's open." They say goodbye to the place that defined their lives, finally able to leave it behind and face their future together.