The first cour builds from Shin's failed attempt on Sakamoto through the one-billion-yen bounty, Sugar Park, the survival tournament with the sniper Heisuke Mashimo, and Lu's kidnapping by a group from the Lab. In the Lab, Shin's past becomes central and Heisuke joins the fight against an invisible assassin. After a bathhouse interlude, the casino battle closes the first part, where Lu's flashback explains how her defence of Wutang made him a key player in her clan.
In the second cour, Sakamoto discovers that the supposed threat from the death row inmates is a distraction designed to lure ORDER into a trap. The real aim of the antagonist X (Slur) is to destroy the Japan Assassins Association. Shin's powers evolve to let him glimpse the future in his fight with Saw. The 22 episodes end mid-story, since the manga continues and a second season has been announced.