The major divergence of the 2001 anime from the manga begins after the initial rounds of the Shaman Fight. In this version, the tournament structure itself eventually dissolves into an all-out race to reach the Great Spirit. A key anime-original plot point is the X-Laws' ultimate plan involving the "Gate of Babylon," a dimensional prison they use in a failed attempt to trap Hao. This event showcases Hao's immense power as he effortlessly escapes, absorbing the spirit of one of their archangels in the process.
The finale is entirely original to the anime. In the final confrontation, Hao successfully reaches and merges with the Great Spirit, achieving god-like power. He defeats all of Yoh's friends and even consumes Yoh's soul after their initial one-on-one battle. However, Manta and the remaining allies manage to journey into the Great Spirit itself to rescue him. The ultimate climax sees all of Yoh's friends and every shaman they have ever met transfer their spiritual power (Furyoku) to Yoh. Empowered by this collective energy—a literal manifestation of the "power of friendship"—Yoh's spirit Amidamaru transforms into a colossal, golden Spirit of Sword. With this power, Yoh is able to overpower Hao's Spirit of Fire and kills him, ending his threat permanently. This makes Yoh the de facto winner and savior, providing a conclusive, action-oriented end to the series where the hero decisively vanquishes the villain, a stark contrast to the manga's ending where Hao is redeemed, not destroyed.