Across its seasons, "The Kardashians" reveals several major life events that were previously known through media headlines but are explored in-depth on the show. A central throughline is the dissolution of Kim's marriage to Kanye West and her subsequent, albeit temporary, romance with Pete Davidson. The series provides behind-the-scenes access to her navigating the divorce and the public fallout. Another major plot point is Kourtney's whirlwind romance with Travis Barker, which culminates in their multiple wedding ceremonies. The show documents their journey with IVF, their blended family dynamics, and the contrast between Kourtney's newfound happiness and the lingering tension with her ex, Scott Disick.
Perhaps the most significant and dramatic spoiler is the revelation of Tristan Thompson's paternity scandal and its aftermath. The series captures the exact moment the family learns of his infidelity and the birth of his child with another woman. This is followed by the even more shocking reveal that Khloé and Tristan were expecting their second child via surrogate when the news broke. The show details Khloé's emotional turmoil as she welcomes her son into the world as a single mother, grappling with the profound betrayal. This storyline becomes a cornerstone of the show's emotional weight, showcasing Khloé's resilience and the family's protective instincts. Later seasons also delve into the growing professional and personal tensions between Kim and Kourtney, particularly surrounding Kim's creative direction for a Dolce & Gabbana fashion show so soon after the brand had designed Kourtney's wedding wardrobe, leading to accusations of a lack of originality and respect for Kourtney's unique moments.