Set immediately after the harrowing events of 28 Years Later (2025), 28 Years Later: The Bone Temple shifts focus to the desolate, lawless landscape of mainland Britain. Young Spike, having fled his isolated sanctuary on Lindisfarne, finds himself absorbed into "The Jimmies," a menacing, cult-like gang of acrobatic raiders who roam the wasteland. Governed by the terrifyingly charismatic Sir Lord Jimmy Crystal, the group enforces bizarre initiation rituals and brutal doctrines upon its members, forcing Spike to navigate an increasingly terrifying moral landscape to stay alive.
Concurrently, deep within his ossuary sanctuary known as the Bone Temple, the eccentric physician Dr. Ian Kelson continues his lone, obsessive research into the Rage Virus. Rather than treating the infected as mere mindless monsters, Kelson attempts an unconventional therapeutic approach on Samson, a massive "Alpha" infected whose immense physical presence conceals lingering sparks of human cognition. As Kelson's medical breakthroughs push the boundaries of science and faith, the erratic path of Jimmy Crystal’s murderous cult threatens to crash into Kelson’s fragile haven, bringing about a violent convergence of madness, science, and survival.
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