The Setup & TVA Betrayal: After Wade's interview with Happy Hogan in 2018 fails, he abandons superheroism. Six years later, Mr. Paradox pulls Wade into the TVA, offering him a spot in the main MCU timeline (Earth-616). Paradox reveals that Earth-10005 is slowly dying because its "Anchor Being"—the original Wolverine who died in Logan (2017)—is gone. To save time, Paradox plans to use a rogue device called the "Time Ripper" to disintegrate Earth-10005 in hours rather than thousands of years.
The Wolverine Hunt & The Void: Wade steals a TemPad and searches the multiverse for a replacement Wolverine. He retrieves a Logan variant who let his world's X-Men be murdered by humans while he was drunk in a bar. When Wade presents him to Paradox, Paradox reveals that an Anchor Being cannot simply be replaced and banishes both into The Void.
The Resistance: In The Void, they are captured by Cassandra Nova, who uses telepathy to stick her hands directly into their brains. They escape and meet the Void Resistance: Johnny Storm (Human Torch), Eric Brooks (Blade), Elektra Natchios, Remy LeBeau (Gambit), and Laura (X-23). After Cassandra brutally kills Johnny Storm (having been tricked into doing so by Deadpool revealing Johnny’s profane insults about her), the team launches an attack on Cassandra’s fortress.
The Climax: They neutralize Cassandra by placing Juggernaut’s helmet on her head. However, after Pyro shoots Cassandra on Paradox's secret orders, Logan removes the helmet to let Cassandra heal out of compassion. In gratitude, Cassandra uses a Doctor Strange sling ring to open a portal back to Earth-10005. However, upon learning about the Time Ripper, Cassandra goes mad with power, follows them, and attempts to use the machine to erase all timelines, leaving only The Void under her supreme reign.
The Ultimate Sacrifice & Ending: To destroy the Time Ripper, someone must connect the matter and antimatter power streams—a task that will instantly vaporize anyone attempting it. Wade locks Logan out to sacrifice himself, but Logan breaks through the door. Holding hands, their combined mutant healing factors allow them to withstand the energy pulse, obliterating Cassandra Nova and destroying the machine. High-ranking TVA Officer Hunter B-15 arrives, arrests Paradox, and reveals that Wade and Logan’s action preserved Earth-10005. In the final scene, Logan and Laura are officially integrated into Wade’s timeline, enjoying a celebratory dinner with Wade’s loved ones and Dogpool.