In the humid urban sprawl of Brisbane, Australia, Hank Malone (Alan Ritchson), a stoic former Army Special Forces operative haunted by the tragic loss of his daughter to illness, seeks quiet atonement. Maintaining his hard-won sobriety while living in solitude on a river houseboat, Hank earns an unassuming living as an elite independent courier—a specialized "runner" hired to transport delicate packages across the region with zero questions asked.
His routine takes a perilous turn when a high-priority dispatch assignment from his handler connects him at the airport with Ben Bishop (Owen Wilson), an affable and chatterbox medical courier. Hank discovers that Ben's strictly climate-controlled cargo is an extraordinarily rare donor liver needed for an emergency transplant to save the life of seven-year-old Ellie Baker (Scarlett Crabtree), who is hospitalized nearby under the care of Dr. Meredith Ainsley (Kate Box) and her desperate mother, Kate (Leila George).
The straightforward mercy mission quickly disintegrates into a violent, high-speed siege when heavily armed cartel mercenaries, led by the ruthless Damián Zaldívar (Rodrigo Santoro), ambush the pair. Desperate to secure the rare organ for his own syndicate's dying matriarch, Damián initiates a relentless citywide manhunt across Queensland, forcing Hank to reignite his lethal tactical skills and work alongside Ben to deliver the fragile package before the biological clock runs out.
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