The central twist of "Shutter Island" is the revelation that the protagonist is not who he appears to be. U.S. Marshal Edward "Teddy" Daniels is, in fact, Andrew Laeddis, the 67th patient at Ashecliffe Hospital. He has been a patient for two years, ever since he murdered his manic-depressive wife, Dolores Chanal, after she drowned their three children. The entire investigation into the 'missing' patient Rachel Solando is an elaborate role-playing therapy orchestrated by his psychiatrist, Dr. Sheehan (posing as his partner, Chuck Aule) and Dr. Cawley.
This radical experiment is a last-ditch effort to force Andrew to confront his trauma and break his delusion, as the alternative is to be lobotomized due to his violent tendencies. The names are anagrams: Edward Daniels is an anagram of Andrew Laeddis, and Rachel Solando is an anagram of Dolores Chanal. After being presented with the truth in the lighthouse, Andrew appears to accept his reality. However, the next morning he seemingly relapses, referring to Dr. Sheehan as 'Chuck' and talking about leaving the island. This perceived failure of the therapy leads the doctors to proceed with the lobotomy. But his final line to Sheehan, "Which would be worse: to live as a monster, or to die as a good man?", reveals that his relapse is a charade. He is lucid and aware of his horrific past, but he consciously chooses the oblivion of lobotomy over living with the unbearable guilt of being a 'monster'.