The narrative of "The Intouchables" is framed by a flash-forward, opening with Driss recklessly driving Philippe's Maserati through Paris, leading to a police chase. The film then unfolds as a flashback, detailing how their friendship began and developed. The central plot revolves around their growing bond, with Driss encouraging Philippe to be more assertive and to pursue a romantic relationship with his epistolary pen pal, Eléonore. A key plot point is Philippe's fear of meeting Eléonore, as she is unaware of his disability. He even sends her a picture of himself from before his accident. He eventually gets cold feet and stands her up on their planned date.
A significant turning point occurs when Driss realizes he must take responsibility for his own family, whose problems have been escalating in his absence. Feeling that Driss should not have to spend his life pushing a wheelchair, Philippe releases him from his job. After Driss leaves, Philippe sinks into a deep depression, refusing to take care of himself and rejecting a series of new caregivers. In a moment of concern, Philippe's aide, Yvonne, calls Driss for help. Driss returns, and this is where the film catches up to the opening scene. Driss takes Philippe on a joyride to the coast. The ending reveals Driss's ultimate act of friendship: he has arranged a lunch date for Philippe. When they arrive at the restaurant, Driss reveals that Philippe will not be dining with him, but with Eléonore. Driss wishes him luck and leaves. From the window, Philippe watches Driss smile at him before walking away. Eléonore arrives, and she and Philippe smile at each other, suggesting the start of a new chapter for him. The film concludes with footage of the real Philippe Pozzo di Borgo and Abdel Sellou, revealing their enduring friendship.