The Quintessential Quintuplets Movie definitively resolves the central mystery of the series: Futaro Uesugi chooses to marry Yotsuba Nakano. The film builds to this reveal during the final day of the school festival. After having significant moments with each sister, Futaro asks them to wait for him in separate classrooms. He makes his way to Yotsuba's classroom and confesses his love for her.
Initially, Yotsuba rejects him, overwhelmed by guilt and the belief that she doesn't deserve happiness at the expense of her sisters. This rejection leads to a key sequence where the film delves into her past, revealing the full extent of her history with Futaro. She was the girl he met in Kyoto as a child—the one who inspired his studious nature—and has loved him ever since. Her selfless support for her sisters was a way of atoning for past selfish behavior. Futaro catches up to her and reaffirms his feelings, explaining that he chose her not because of their past, but because her constant, unwavering support brought him happiness and he couldn't imagine a future without her. She finally accepts his confession after being encouraged by her sisters, who, despite their own heartbreak, give her their blessing.
The film then flash-forwards five years to their wedding day. In a final, playful "Quintuplet Game," all five sisters dress in identical wedding gowns to test Futaro. He is now able to tell them apart easily, identifying each one before finally kissing his bride, Yotsuba, concluding their story. The ending establishes that all the sisters have found success and happiness in their chosen careers: Ichika is a famous actress, Nino and Miku have opened their own cafe, and Itsuki has become a teacher.