The central twist in "The Silence of the Lambs" is the misdirection orchestrated by Hannibal Lecter that sends the FBI on a wild goose chase to the wrong house, while Clarice, following her own instincts and Lecter's more subtle clues, finds herself at the actual home of the killer, Jame "Buffalo Bill" Gumb. This is a masterfully crafted sequence of cross-cutting that builds suspense to an almost unbearable level. The audience, along with the heavily armed FBI team, believes they are about to storm the killer's lair, only to discover an empty house. Meanwhile, Clarice, alone and vulnerable, comes face-to-face with the man she's been hunting.
The film's climax takes place in Gumb's terrifying, labyrinthine basement, where he stalks Clarice in complete darkness using night-vision goggles. This sequence is a harrowing depiction of the hunter becoming the hunted. Just as it seems Gumb is about to strike, Clarice, guided by the sound of his revolver cocking, spins around and fires, killing him. In the end, she rescues Catherine Martin, Buffalo Bill's latest captive. A significant plot turn is Lecter's gruesome and ingenious escape from his temporary holding cell. He brutally murders his guards and uses the skin from one of their faces as a mask to fool the paramedics and be taken away in an ambulance. The film's chilling final scene reveals that Lecter is at large, having called Clarice from a tropical location where he is stalking his next victim, the smarmy Dr. Chilton. His final line to Clarice, "I'm having an old friend for dinner," is a darkly humorous and terrifying confirmation that the monster is free and will kill again.