The car crash is the centre of everything. Octavio's story leads up to it. His dog Cofi becomes a dogfighting champion, and the rivalries and violence around the fights end with Octavio fleeing in a car chase that ends in the collision. His plans to escape with Susana collapse, which proves her grandmother's saying about telling God your plans.
Valeria's story straddles the crash. She is the passenger in the other car. Daniel has just left his family for her, the "ideal woman." After the crash he ends up pushing her in a wheelchair in their new apartment. Her career and self-image fall apart, and so does the fantasy that drove Daniel's choice.
El Chivo witnessed the crash and takes the wounded Cofi home. He nurses the dog back to health, but Cofi kills El Chivo's other dogs. In the dog, El Chivo sees himself: a creature made into a killer. This leads him to refuse the killing he was hired to do. Instead, he tries to reclaim his lost loyalty to his daughter Maru, who believes he is dead. Iñárritu said the ending was always meant to be about El Chivo's redemption. The film ends with him heading into a bleak, uncertain future. Once you know this, the whole triptych reads as a movement from blind, reckless passion toward a painful moral awakening.