The narrative begins with Mary Shelley's spirit possessing Ida in 1936 Chicago, causing Ida to expose crime boss Lupino's syndicate before being killed by henchmen Clyde and James and buried in a pauper's grave. Frank and Dr. Cornelia Euphronius exhume Ida's corpse and successfully reanimate her using city electrical grids. Frank attempts to domesticate her by falsely claiming she is his loving wife who suffered memory loss.
The deception collapses as the Bride experiences sensory overload and encounters external brutality. When Frank kills two assailants outside a nightclub, the pair flee as fugitives, sparking countercultural riots among youth who embrace her rebellious aesthetic. The chase culminates when Detective Wiles and police shoot Frank down. The Bride carries his body back to Euphronius' lab for reanimation, but the police breach the room and gun down the Bride, leaving both corpses side-by-side on the operating table.
In the final twist, a lightning strike hits the laboratory electrodes, causing Frank and the Bride's hands to twitch and lock together before cutting to black, confirming their resurrection and eternal defiance.