Doctor Stranger follows Park Hoon, a South Korean prodigy who is trapped in North Korea alongside his renowned cardiothoracic surgeon father after being betrayed by high-ranking politicians. Raised in a secretive, brutal medical research facility, Hoon masters extraordinary surgical techniques under oppressive duress while falling deeply in love with Song Jae-hee. When a risky defection attempt in Budapest separates them, Hoon manages to escape to South Korea, carrying the singular goal of locating and rescuing his lost love.
In Seoul, Hoon works as an unconventional doctor at the prestigious Myungwoo University Hospital. There, he encounters Han Seung-hee, an enigmatic anesthesiologist with an identical face and physiology to Jae-hee, who adamantly denies knowing him. As Hoon navigates the rigid hierarchy of South Korean medical institutions, he becomes entangled in a high-stakes surgical rivalry against Han Jae-joon, an elite Harvard-trained surgeon harboring his own covert vendetta against the hospital's founding family.
As medical rivalries escalate into multi-round surgical tournaments, Hoon discovers that his presence at Myungwoo is not coincidental. He and his peers are pawns in an elaborate geopolitical conspiracy involving prime ministerial ambitions, covert operatives, and life-and-death power plays between North and South Korea, forcing each doctor to define what it truly means to heal rather than destroy.
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