In the early 20th century, Karamakate, a powerful Amazonian shaman and the last survivor of his tribe, lives in voluntary isolation in the depths of the Colombian jungle. His solitude is interrupted twice, decades apart, by two Western scientists: Theodor Koch-Grünberg in 1909 and Richard Evans Schultes in 1940. Both men are searching for the sacred yakruna plant, a rare psychedelic flower believed to possess healing powers and the ability to teach men to dream.
The film weaves these two timelines together as parallel journeys down the same river. In the first, a young, resentful Karamakate agrees to help the sickly Theo only because he believes the white man can lead him to other survivors of his people. Decades later, an aged, forgetful Karamakate—who fears he has become a chullachaqui, a hollow shell of his former self—guides Evan, hoping to reclaim his lost memories. As they travel, the film reveals the devastating scars left by the rubber barons and missionaries, portraying the jungle not just as a setting, but as a wounded, living protagonist.
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