The narrative is initiated in Macau when factory owners spike Lee Gun's drink with an industrial aphrodisiac to engineer a scandal. Kim Mi-young inadvertently consumes the drugged water, and a hotel room mix-up (Room 2006 versus 2009) leads to their accidental one-night stand. Mi-young's subsequent pregnancy prompts Gun's grandmother, Chairwoman Wang, to arrange a shotgun contract marriage to secure the family bloodline.
In Episode 11, acute stress triggers neurological symptoms in Gun, causing temporary amnesia where he forgets Mi-young and believes he is still dating Kang Se-ra. Upon regaining his memory, Gun learns that early symptoms of his family's fatal Huntington-like hereditary disorder may be surfacing. Desperate to spare Mi-young from becoming a caretaker and widow, Gun cruelly severs their relationship. During their confrontation in Episode 12, Mi-young is struck by a vehicle and suffers a miscarriage, losing their child Gae-ddong, which prompts her to leave for Paris alongside Daniel Pitt.
Following a three-year time jump, Mi-young returns as the acclaimed artist Ellie Kim. Gun, secretly grieving, uses the pseudonym "Lee Young-ja" to purchase her tribute painting of their lost child. Meanwhile, Daniel discovers that Kang Se-ra is his long-lost biological sister. Mi-young eventually discovers Gun's secret nursery and video diary documenting his illness and enduring love, confronting him at a press conference. The series concludes happily after medical tests verify Gun's illness is dormant, leading to a true wedding and the birth of healthy twins.