The film utilizes a framing device beginning in 2019 as John prepares to receive his MBE at Buckingham Palace. Flashing back to 1983, it details his school breakdown, where teachers beat his hands with belts to curb his twitches, his father abandons the family, and young John attempts suicide by drowning. He survives and is prescribed heavy neuroleptics, spending over a decade chemically dulled and isolated.
In the mid-1990s, childhood friend Murray introduces John to his mother Dottie, who helps John wean off his heavy sedatives and secures him work with Tommy at a community youth centre. John flourishes, discovering purpose in mentoring children showing early symptoms of Tourette's. Following Dottie's death from cancer, John commits his life to public advocacy. The narrative returns to the MBE investiture, showing that while John has earned national respect, his condition remains an incurable daily reality, closing on an image of dignity rather than a miraculous Hollywood cure.