Love, Rosie follows the lives of Rosie Dunne and Alex Stewart, two inseparable best friends growing up in the United Kingdom. Their bond is tested on Rosie's 18th birthday when a drunken kiss is forgotten by one and misinterpreted by the other, setting off a chain of events that keeps them romantically apart for the next twelve years. While Alex moves to Boston to pursue a medical degree at Harvard, Rosie's plans for hotel management school are derailed by an unplanned pregnancy following a one-night stand with the school's popular jock, Greg.
As the years pass, the film tracks their lives through letters, emails, and occasional awkward visits. Alex navigates high-society relationships in America, while Rosie raises her daughter, Katie, as a single mother in England. Despite marriages, career shifts, and thousands of miles, the narrative explores the magnetic pull between them, focusing on the frustration of the "right person, wrong time" trope as they repeatedly fail to synchronize their feelings.
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