Set in New York City between 1981 and 1984, the film chronicles the onset of the HIV/AIDS crisis through the eyes of Ned Weeks, a writer and activist based on playwright Larry Kramer. As a mysterious cancer begins killing gay men, Ned joins forces with Dr. Emma Brookner, a polio survivor and physician who is one of the few medical professionals taking the epidemic seriously.
Ned helps found the Gay Men's Health Crisis (GMHC) but finds himself at odds with the group's president, Bruce Niles, and the board over his confrontational tactics. While fighting for government recognition and funding, Ned falls in love with Felix Turner, a closeted fashion reporter for The New York Times. The film depicts their tragic romance alongside the escalating political battle against a backdrop of fear, denial, and mounting death tolls.
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