The film follows Paul's unstoppable shrinking after his exposure to the cloud at sea. As he decreases from meters to centimeters, his wife Élise and daughter Mia struggle to accommodate his tiny form. A domestic incident occurs when the family cat attacks Paul; during the scramble, Paul tumbles down a loose floorboard grate into the dark basement.
In the basement, Paul is stranded. Élise finds a scrap of Paul’s torn, blood-stained shirt near the grate and tragically concludes that the cat killed and consumed him. Upstairs, the family grieves and eventually moves forward, unaware Paul is alive directly beneath their feet.
Downstairs, Paul endures a grueling survival struggle. He fashions weapons out of a sewing needle and thread, builds shelter in a matchbox, and survives on crumbs. His climax involves a terrifying, prolonged duel with a cellar spider over a piece of food. Paul successfully slays the spider with his needle, but his victory offers no physical escape: his shrinking does not stop.
In the final sequence, Paul shrinks smaller than dust particles and cellular structures. Passing through a basement window grate into the night air, he gazes up at the stars. Realizing that as he shrinks toward absolute nothingness, the microscopic realm becomes an endlessly sprawling galaxy, he experiences complete peace. His final revelation confirms that to God and the universe, there is no small or large—all existence is infinite.